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Carcinogenesis In a very lifetime carcinogenicity review carried out in B6C3F1 mice, methylphenidate triggered a rise in hepatocellular adenomas, As well as in males only, a rise in hepatoblastomas in a each day dose of close to sixty mg/kg/day. This dose is about two situations the MRHD of 60 mg/day supplied to youngsters on mg/m2 basis.Prescribe